Challenges of adapting to online teaching during the COVID-19 pandemic in Compulsory Secondary Education

The pandemic caused by COVID-19 meant an important change in the approach to teaching-learning strategies at all educational levels, since the face-to-face model had to be forcedly adapted to other hybrid or online models. Different national and international reports advocated carrying out this transformation for the benefit of all students, regardless of health measures. This research aims to analyze the variability of teaching methodologies of Compulsory Secondary Education and Baccalaureate teachers in face-to-face format with the didactic actions undertaken for the development of online activities during the confinement period of the 2019-2020 academic year in centers of the Community of Madrid. For this, a questionnaire was designed that, online, was sent to all the centers in which the students of the Master's Degree in Teacher Training (UCM) carried out their curricular practices, obtaining a total of 226 responses. For data analysis, a descriptive analytical model was carried out, using a cross-sectional design to determine differences between the members of the sample. The conclusions show that the low use of digital resources in the classroom on a regular basis is related to the increase in difficulties and discomfort of teachers in facing virtual teaching situations. In turn, the difficulties and discomfort of the younger teachers is similar to that of the older teachers, so some years of experience in the educational center are necessary to implement virtual teaching. © 2023, AUFOP. All rights reserved.

Biodiversity, Urban Quality Life and Air Quality Indices for Hotspot Detection of Transformation Opportunities in Cities: A Case Study in Barcelona

Half of the world's population lives in cities, where usually there are few little green space and there are also high levels of air pollution. Moreover, the traditional urbanization of cities contributes to climate change, promotes the loss of global biodiversity and induces serious health problems for citizens. Both climate change and the loss of biodiversity affect negatively to the ecosystems and therefore human health, as they are responsible for providing clean air, food, fresh water, medicines, renewable resources. . . This deterioration increases significantly the risk of human-borne infectious diseases such as coronavirus or HIV. The ability we have to re-naturalize anthropogenic spaces and learn to generate spaces for coexistence will be key for the future of our society. The research presented in this paper aims to do a step forward to achieve that ability by working in three schools of the city of Barcelona and their surroundings. Among other actions, in this project, a diagnosis of neighborhood has been carried out. The diagnosis includes the identification and quantification of relevant indicators regarding neighborhood's biodiversity and also the quality of daily life and the analysis of pollutants (NO2 and PM10) near the schools during the 2021-2022 school year. All these information has been merged in a single geographic data base and relevant hotspots where to act have been identified. The information has been shared with city council and citizens. Copyright © 2023 by SCITEPRESS – Science and Technology Publications, Lda.

Distance traveled in times of pandemic: an endogenous switching regression approach

This paper studies the change in the distance traveled by domestic tourists considering the pre- and post-pandemic outbreak summer periods of 2019 and 2020. Using representative monthly microdata involving more than 31,000 trips conducted by Spanish residents, we examine the heterogeneity in behavioral adaptation to COVID-19 based on sociodemographic and trip-related characteristics. To account for selection effects and the potential change in the population composition of travelers between the two periods, we estimate an endogenous switching regression that conducts separate regressions for the pre- and post-pandemic periods in a unified econometric framework. Our results point to heterogeneous shifts in the distance traveled by domestic travelers after COVID-19 outbreak per sociodemographic group, with notable differences by travel purpose and lower relevance of traditional determinants like income.

Learning derived from the implementation of a pedagogical device in remote teaching conditions by Covid-19

The experience of implementing a pedagogical device in a rural educational institution is presented. The objective is to contribute to the study of the incorporation of digital media in schools through the description and analysis of certain pedagogical adaptations that took place in remote teaching conditions due to Covid-19. Under the action-research approach in education, high school students were guided and accompanied in the creation of short videos on environmental promotion and sustainable development. From a qualitative analysis, the following were identified as important adaptations: 1) more flexible times, rhythms, and stages of teaching and learning;2) the agency and mobilization of digital skills by the teacher to strengthen the pedagogical relationship;and 3) the emphasis placed on the communicative aspects of digital media to favor the creation and expression of students. In general, a reflection on the resources, means and strategies that are needed to respond to the heterogeneity of educational scenarios or unprecedented conditions such as those generated by the pandemic is addressed.

SARS-CoV-2 and methemoglobinemia in the neonatal period. Case report

INTRODUCCTION: Methemoglobinemia (MetaHb) is a condition where the erythrocyte is unable to release oxygen into tissues causing tissue hypoxia and metabolic acidosis with high lactate. In adult patients with SARS-CoV2 infection, some cases of coexistence of MetaHb and refractory hypoxemia have been reported;although there are no reports of this association in the neonatal stage. CLINICAL CASES: We show two cases of premature newborns with SARS-CoV-2 infection who had multisystemic deterioration and MetaHb in the second to the thrid week of life, without microbiological isolation, or temperary relationship with known MetaHb triggers, normal G6PD levels, and partial response to exchange transfusion or infusion of methylene blue. CONCLUSION: The relationship between MetaHb and SARS-CoV-2 infection is still unknown, but its pro-inflammatory activity has recently been documented, which can increase cytokine storm and worsen the evolution and prognosis of the patient with moderate to severe infection. Further studies of these associations are therefore necessary to enable timely interventions. © 2023 Instituto Nacional de Pediatria. All rights reserved.

Preference Shifts During Health Shocks: Foreign Tourists' Expenditure-Price Elasticity Throughout the Pandemic

This study evaluates the changes in the expenditure-price elasticities of foreign tourists in the summer periods of 2019, 2020, and 2021. We first develop a theoretical characterization that combines microeconomic, loss aversion, price inequality and precautionary savings theories. Next, exploiting microdata for more than 34,000 foreign tourists visiting Spain, we estimate OLS and quantile regressions to empirically examine the expenditure elasticities with respect to the prices of transport services, leisure activities and bars and restaurants at the destination (17 regions). We find that (i) the expenditure-price elasticity of transportation (leisure activities) increases (decreases) during the pandemic, whereas that of bars and restaurants remains unchanged, (ii) foreign tourists are comparatively less expenditure-price elastic at high expenditure levels in transportation and bars and restaurants, and (iii) expenditure-price elasticities are highly heterogeneous depending on the origin country. Managerial and theoretical implications of the findings for firms' pricing strategies are discussed.

Glioblastoma Susceptibility to SARS-CoV-2: Analysis of Cancer Stem Cells and Immune Tumor Microenvironment on Human Brain, Patient-Derived Tumors, and Organoid Models

INTRODUCTION: Glioblastoma (GBM) is the most common and deadliest primary brain tumor, characterized by chemoradiation resistance and an immunosuppressive tumor microenvironment (TME). SARS-CoV-2, the COVID-19 virus, produces a significant proinflammatory response and a spectrum of clinical presentations after central nervous system infection. METHOD(S): Patient-derived GBM tissue, primary cell lines, and organoids were analyzed with immunohistochemistry and pixel-line intensity quantification. Data from tumor-bulk and single-cell transcriptomics served to describe the cell-specific expression of SARS-CoV-2 receptors in GBM and its association with the immune TME phenotype. Normal brain and iPSC-derived organoids served as controls. RESULT(S): We demonstrate that patient-derivedGBMtissue and cell cultures express SARS-CoV2 entry factors such as ACE2, TMPRSS2, and NRP1. NRP1 expression was higher in GBM than in normal brains (p<0.05), where it plays a crucial role in SARS-CoV-2 infection. NRP1 was expressed in a cell-type and phenotype-specific manner and correlated with TME infiltration of immunosuppressive cells: M2 macrophages (r = 0.229), regulatory T cells (r = 0.459), NK cells (r = -0.346), and endothelial cells (r = 0.288) (p < 0.05). Furthermore, gene ontology enrichment analysis showed that leukocyte migration and chemotaxis are among the top 5 biological functions mediated by NRP1 (p < 0.05). We found our GBM organoids recapitulate tumoral expression of SARSCoV- 2 entry factors, which varies based on distance from surface as surrogate of TME oxygenation (p < 0.05). CONCLUSION(S): GBM cancer cells and immune TME cells express SARS-CoV-2 entry factors. Glioblastoma organoids recapitulate this expression and allow for currently undergoing studies analyzing the effect of SARS-CoV-2 infection in GBM. Our findings suggest that SARSCoV- 2 could potentially target GBM, opening the door to future studies evaluating SARS-CoV-2-driven immune modulation.

Innovative Approaches to Managing Scale

Enrollments in computer science courses and majors are at or exceeding capacity at the college level. This context drives local innovations that may benefit individuals across the SIGCSE community. The panelists will share how, in the context of booming enrollments and COVID, they strive to protect faculty time, engage students in larger classes, take advantage of scale, improve student-TA interactions, motivate faculty to teach larger classes, and better monitor students in large classes. During the panel Q&A, attendees will be invited to share additional strategies live on Course.Care, which will then be disseminated through CSTeachingTips.org.

It Seemed Like a Good Idea at the Time (COVID-19 edition)

Conference presentations usually focus on successful innovations: new ideas that yield significant improvements to current practice. Yet we often learn more from failure than from success. In this panel, we present five case studies of "good ideas" for improving CS education (most related to the COVID-19 pandemic) that didn't go as planned. Each contributor will describe their "good idea", the situation that resulted, and wider lessons for the CS community.

TechnologyWe Can't Live Without! (COVID-19 edition)

This panel is the evolution of a Technology that Educators of Computing Hail (TECH) Birds of a Feather session held at SIGCSE for seven years, grew into popular panels for many years [2-4, 6, 7], and served as a springboard for a regular column in ACM Inroads [1, 5, 9]. It will provide a chance for seasoned middle school, high school, and university educators to showcase the technologies they can't live without, what problems they solve, and how to use them. This year, we asked our panelists to highlight any technology in particular that helped them survive (and possibly even thrive!) during their remote teaching.

Aggression, mini-aggression, and abuse against health care workers during the COVID-19 pandemic

Introduction: COVID-19 pandemic brought multiple negative consequences that go beyond the direct damage caused by the disease and that affect health systems as well. Complaints of attacks against health care workers became frequent and concerning. The objective of this survey was to characterize the frequency and type of violent behavior against front-line professionals in Latin America. Material(s) and Method(s): A cross-sectional electronic survey was carried out between January 11th to February 28th, 2022. Different health care workers from Latin America who have been delivering care at least from March 2020, regardless of whether they assist or not patients with COVID- 19 were included. A non-probabilistic snowball sampling was performed, and the survey was Results: The survey was responded by 3,544 participants from 19 countries (Figure 1);58.5% were women, and the mean age was 41.9+/-11 years. The 70.8% were doctors, 16% nurses, 3.4% physiotherapists, and the remaining 9.8% had other functions within the health team. About 85.1% of physicians were specialists: 33.9% were cardiologists, 14.4% were intensivists or emergency physicians, 10.9% had some surgical specialty, 7.7% were pediatricians or related subspecialties, and the remaining 33.1% had other specialties. The 36.3% and 28.8% worked in public and private practice respectively, the remaining worked in both. Direct and regular care to COVID-19 patients was provided by 74.7% of all contestants. Among the participants, 54.8% reported acts of violence: 95.6% suffered verbal violence, 11.1% physical violence, and 19.9% other types. 39.5% of respondents experienced it at least once a week. The acts of violence involved patients' relatives (32%), or patients together with their relatives (35.1%). The victims rated the stress level of these events with an average of 8.2+/-1.8 points (scale from 1 to 10). Approximately half of the health personnel who suffered an assault experienced psychosomatic symptoms after the traumatic event (Figure 2). Among the victims of violence, 56.2% considered changing their care tasks, and 33.6% abandoning their profession. However, only 23% of the health personnel attacked stated that they had made some type of legal action regarding these acts. In a logistic regression model, doctors (OR 1.95, p<0.01), nurses (OR 1.77, p=0.001), and administrative staff (OR 3.20, p<0.01) suffered more violence than other health workers. Women more frequently suffered violence (OR 1.56, p<0.01), as well as those who worked with patients with COVID-19 (OR 3.59, p<0.01). Conversely, a lower probability of violence was observed at older ages (OR 0.96, p<0.01). Conclusion(s): We detected a high prevalence of violence against health personnel in Latin America during the current pandemic. Those caring for COVID-19 patients, younger staff, and women were found to be more vulnerable. It is imperative to develop strategies to mitigate these acts and their repercussions on the health team. (Figure Presented) .

Prospective study of pulmonary embolism in patients with SARS CoV-2 pneumonia with high levels of D Dimer

Pulmonary embolism (PE) is common among hospitalized adults with SARS CoV-2 pneumonia. D-dimer (DD)>1 mug/mL has been found to be a severity risk factor. However, most of the studies are based on retrospective data and the real prevalence is unknown Objectives: To evaluate the prevalence of PE in patients with SARS CoV-2 pneumonia, regardless clinical suspicion. Demographic and laboratory data, comorbidities, and clinical outcomes were compared between patients with and without PE Methods: Single-center prospective study. All consecutive cases of SARS CoV-2 pneumonia with DD>1 mug/mL underwent computed tomography pulmonary angiography Results: 179 patients (64 (55-74 years), 65% male) were included. PE was diagnosed in 71 patients (39.7%), mostly with a peripheral location and low thrombotic load (Qanadli score 10%). We did not find disparity in PE prevalence between men and women, and between obese and not obese patients. There were no differences in the intensive care unit admission rate. Mortality rate was 8.5% in patients with PE vs. 3.7% in those without PE, but the differences were not significant. Patients with PE had more history of cardiovascular disease and required more fractional inspired oxygen. DD, platelet distribution width (PDW), neutrophil-lymphocyte ratio (NLR), DD-lactate dehydrogenase ratio (DD/LDH), and DD-ferritin ratio values were significantly higher among PE patients. ROC analysis showed that PDW and DD/LDH had the greatest area under the curve Conclusion(s): Patients with SARS CoV2 pneumonia and DD>1mug/mL presented a high prevalence of PE, regardless of clinical suspicion. PDW, NLR, DD/LDH and DD/Ferritin may help to identify patients with high risk of PE.

Risk factors for mortality in COPD patients with COVID19 admitted to Intensive Care Unit

Background and aim: Patients with Chronic obstructive pulmonary disease (COPD) and COVID-19 have increased risk of hospitalization and Instensive Care Unit (ICU) admission (1). Aims and objectives: To indentify risk factors for intrahospital mortality in COPD patients with COVID-19 admitted to Spanish ICUs. Method(s): Demographic and clinical data during ICU admission were recorded using REDCap on all patients hospitalized for COVID-19 in 70 Spanish ICUs (2). We described the baseline clinical characteristics of COPD compared to other chronic respiratory disease (CRD) and to the overall population. We identified the risk factors for intrahospital mortality of COPD patients receiving invasive mechanical ventilation (IMV) and for those COPD receiving noninvasive respiratory support (NIRS). Result(s): Two hundred and sixty-eight ICU patients (5%) had COPD out of 5196 included. No differences were found between COPD, CRD or the overall population in the rates of IMV (76-78%) vs NIRS (22-24%). COPD intrahospital mortality was much higher in the IMV subgroup (58%). Independent risk factors for intrahospital mortality in the COPD+IMV or COPD+NIRS were: age and chronic Kidney disease or hypertension, respectively. Previous NIRS in COPD+IMV group was protective for intrahospital mortality (Figure). Conclusion(s): New strategies are needed to reduce the high intrahospital and 90-days mortality of COPD COVID-19 patients admitted to ICU.

Aggression, mini-aggression, and abuse against health care workers during the COVID-19 pandemic

Introduction: COVID-19 pandemic brought multiple negative consequences that go beyond the direct damage caused by the disease and that affect health systems as well. Complaints of attacks against health care workers became frequent and concerning. The objective of this survey was to characterize the frequency and type of violent behavior against front-line professionals in Latin America. Material and methods: A cross-sectional electronic survey was carried out between January 11th to February 28th, 2022. Different health care workers from Latin America who have been delivering care at least from March 2020, regardless of whether they assist or not patients with COVID-19 were included. A non-probabilistic snowball sampling was performed, and the survey was Results: The survey was responded by 3,544 participants from 19 countries (Figure 1);58.5% were women, and the mean age was 41.9±11 years. The 70.8% were doctors, 16% nurses, 3.4% physiotherapists, and the remaining 9.8% had other functions within the health team. About 85.1% of physicians were specialists: 33.9% were cardiologists, 14.4% were intensivists or emergency physicians, 10.9% had some surgical specialty, 7.7% were pediatricians or related subspecialties, and the remaining 33.1% had other specialties. The 36.3% and 28.8% worked in public and private practice respectively, the remaining worked in both. Direct and regular care to COVID-19 patients was provided by 74.7% of all contestants.Among the participants, 54.8% reported acts of violence: 95.6% suffered verbal violence, 11.1% physical violence, and 19.9% other types. 39.5% of respondents experienced it at least once a week. The acts of violence involved patients' relatives (32%), or patients together with their relatives (35.1%). The victims rated the stress level of these events with an average of 8.2±1.8 points (scale from 1 to 10). Approximately half of the health personnel who suffered an assault experienced psychosomatic symptoms after the traumatic event (Figure 2). Among the victims of violence, 56.2% considered changing their care tasks, and 33.6% abandoning their profession. However, only 23% of the health personnel attacked stated that they had made some type of legal action regarding these acts.In a logistic regression model, doctors (OR 1.95, p<0.01), nurses (OR 1.77, p=0.001), and administrative staff (OR 3.20, p<0.01) suffered more violence than other health workers. Women more frequently suffered violence (OR 1.56, p<0.01), as well as those who worked with patients with COVID-19 (OR 3.59, p<0.01). Conversely, a lower probability of violence was observed at older ages (OR 0.96, p<0.01). Conclusion: We detected a high prevalence of violence against health personnel in Latin America during the current pandemic. Those caring for COVID-19 patients, younger staff, and women were found to be more vulnerable. It is imperative to develop strategies to mitigate these acts and their repercussions on the health team. Funding Acknowledgement: Type of funding sources: None.Figure 1Figure 2

Impact of the Covid-19 pandemic on the care of patients with chronic arterial disease. A nuclear medicine physician's perspective

Aim/Introduction: The health reorganisation measures, imposed after the serious health emergency resulting from the SARS-CoV-2 pandemic, may have had a negative impact on the follow-up of patients with chronic pathologies. Our intention was to assess their repercussion in our environment, observing what happened in patients with a history of coronary artery disease (CAD) in terms of accesibility and diagnostic performance. Material(s) and Method(s): Retrospective observational study of 756 patients consecutively referred to our Department for myocardial perfusion (MP) studies. Two time groups were established (G1 and G2), both lasting one year, taking as a cut-off point the establishment of the state of health alarm in our country. From the total number of records reviewed 131 patients were selected (mean age 65.74 > 11.03 SD), all with a history of CAD prior to the performance of the MP (G1 56.49%;G2 43.52%). Delay times between test request and test performance were obtained: G1 (17.89 days > 9.85 SD), G2 (16.32 > 20.81 SD) and study results based on two variables, stability or inducible ischaemia. Result(s): In the pre-alarm period (G1) there were more requests for PM studies than in G2 (419 vs 337), with a similar percentage of CAD to total patients (17.66% vs 16.91%). Typical clinical presentation, following the traditional clinical classification, predominated and was statistically significant (p=0.001) for this first group (78.38% vs 52.63%). However, G1 showed a lower number of positive PM results than G2 (37.83% vs 43.85%), and the percentage of total catheterisations performed was also lower (57.14% vs 68%). In relation to the mean delay time between positive PM and catheterisation, a shorter duration was observed for G1 (65.64 days > 46.19 SD) than for G2 (95.41 days > 71.73 SD). No statistically significant differences (p=0.768) were found between the mean ages of patients in the two groups. Conclusion(s): In our health care system, the follow-up of patients with CAD after the establishment of the alarm status was affected by a lower percentage of patients referred to our Department and a longer delay between positive PM and catheterisation. In this period, it is remarkable the higher number of positive PM in patients without typical clinical features. We are unaware of the possible involvement of covid-19 in this situation, currently being investigated by our working group.

Impacts of Covid-19 on air quality, Land Surface Temperature and Urban Heat Island on Local Climatic Zones in the city of Granada (Spain)

The COVID-19 outbreak and the lockdown situation have generated a significant negative impact on the world economy but have provided a unique opportunity to understand the impact of human activity on environmental pollution and how it affects the urban climate. This study takes the city of Granada (Spain) in order to carry out an evaluation of the environmental parameters (So2, No2, Co and O3) obtained through Sentinel 5P images and how they affect the Terrestrial Surface Temperature (TST) and the Surface Urban Heat Island (ICUS) obtained through Sentinel 3 images. Knowing the environmental impact on the TST and ICUS of the different Local Climate Zones (ZCL) of the city will have an impact on future urban resilience studies. As a result, and during the confinement period, the following variations have been obtained with respect to environmental pollutants: So2 (-24.0%), No2 (-6.7%), Co (-13.2%) and O3 (+4.0%). The TST has experienced an average reduction of-8.7 degrees C (-38.0%) while the ICUS has decreased by-1.6 degrees C (-66.0%).

VASCOVID: Hybrid diffuse optical platform combined with a pulse-oximeter and an automatized inflatable tourniquet for the assessment of metabolism and endothelial health in the intensive care

VASCOVID project is developing and testing a hybrid diffuse optical monitor for evaluating endothelial function and metabolism in intensive care including COVID-19. © 2022 The Authors.

THE USEFULNESS of the PATIENT ACTIVITY SCORE-PASS-II to ASSESS DISEASE ACTIVITY during the COVID-19 LOCKDOWN in PATIENTS with RHEUMATOID ARTHRITIS

Background: Many measurement tools are designed to assess disease activity for Rheumatoid Arthritis (RA) patients. One of the most used tools is the Disease Activity Score-DAS28 which assesses the number of painful joints, erythrocyte sedimentation, and a patient's global assessment. The assessment is performed by a clinician and requires laboratory exams. Unfortunately, from March to August 2019, Colombia had one of the strictest responses to the COVID-19 pandemic according to the COVID-19 stringency Index(1). One of the main restrictions was the preventive isolation of older populations, especially those with comorbidities. These restrictions challenged the rheumatology practice because face-to-face consultations were not possible. Due to the above, measurements like the PAS-II score should be used to assess disease activity during the pandemic. Objectives: To describe disease activity according to the Patient Activity Score-PAS-II score patients with RA and compare its results to the most recent DAS28 assessment before the COVID-19 pandemic. Methods: We conducted a descriptive study;patients were followed during the COVID-19-lockdown in a video consultation. The PAS-II score was applied to assess disease activity as an alternative to the DAS28 assessment. The patients were part of an educational program, clinical charts were reviewed to collect the study variables. We collected demographic data and DAS28 before the pandemic started. We present a descriptive analysis of DAS28 severity and the results obtained by the PASS-II score. Results: The educational program enrolled 250 participants;196 patients had complete data. 93% of participants were women, mean age was 64 years IQR (54-67). 43% of participants were married or had a civil union, 26% were single, 20% divorced, and 11% were widowed. Regarding educational level, 25% had fnished elementary school and 39% high school;the remaining 36% had higher education. When we compared the last DAS28 assessed by a rheumatologist between January, and March 2019, 67% of patients were in remission, while in July 2019, the PASS-II score reported that 7% of patients were in remission and 75% had low or minimal activity. Figure 1-Table 1. Conclusion: The PASS score is a helpful tool to assess disease activity in patients with RA, especially in situations where the patient cannot see a rheumatologist in a face-to-face consultation;however, patients in severe disease activity should not delay the consultation with a clinician. As other studies have demonstrated, patient-reported outcome measures should be adopted in clinical practice as an alternative for treat-to-targe strategies(2). Further studies should be conducted to assess the impact of the pandemic in countries with high levels of restrictions in the course of RA.

HUMORAL IMMUNE RESPONSE to SARS-COV-2 VACCINE in RITUXIMAB-TREATED PATIENTS

Background: Vaccination against SARS-CoV-2 has shown efficacy and safety in patients with chronic infammatory rheumatic disease, similar to the general population. However, in patients treated with rituximab (RTX) it is known that usually have a lower vaccination response rate (1-2), and recent studies suggest that it also happens with the new SARS-CoV 2 vaccine (3), which entails an increased risk of hospitalization and mortality in this specifc group of patients. Objectives: To describe humoral immune response to SARS-CoV-2 vaccine in rituximab-treated patients after one and six months from the vaccination, and study if there is any other factor associated with a lower response rate. Methods: Prospective analysis of a cohort of patients treated with RTX who received the SARS-CoV-2 vaccine between the months of April and October 2021. Demographic and medical data were collected through electronic medical records. Blood tests and serologies with levels of antibodies against SARS-CoV-2 were performed one and six months after having received the vaccine against SARS-CoV-2. The administration of a booster dose of the vaccine was recorded. A descriptive and statistical analysis of the data was carried out using the SPSS program. Results: From a cohort of 41 patients, of whom 81,4% were women with a mean age of 56 (13,4 SD) years, vaccine response rate was only 36,7% after a 6-month follow-up. The 88,4% of them received a booster dose of the vaccine, but this failed to produce a vaccine response in any of the patients who had not developed it with the previous ones. One patient became infected after receiving one dose of the vaccine and failed to develop a serological response either. Hypogammaglobulinemia was associated with a statistically signifcant lower probability of vaccine response (p=0,04). A trend of lower vaccination response rate was observed in patients who had received the last cycle of RTX in the 6 months prior to vaccination (p=0,058). In addition, the antibody levels developed one month after vaccination were statistically signifcantly correlated with the time between the last RTX cycle and vaccination (p=0,014) and also with CD19 B cells levels prior to vaccination (p<0,001);however, there was no correlation with the antibody levels detected at the 6-months serology. No statistically signifcant differences were found in relation to the number of previous cycles of RTX, concomitant treatment with synthetic disease-modifying drugs (DMARDs) or corticosteroids. Conclusion: In our sample, after a 6-month follow-up only 36,9% achieved a vaccine response against SARS-CoV-2, which did not improve despite the administration of a booster dose. Hypogammaglobulinemia, the time between the last RTX cycle and vaccination (at least 6 months), and previous CD19 B cells levels signifcantly influenced in the development of a humoral response to the vaccine.

Development of virtual outreach strategies to supply cancer education and prevention information during the COVID-19 pandemic

Background: The COVID-19 pandemic has forced many individuals to continue virtually via Zoom. To accommodate this change and remain accessible, the University of Arizona Cancer Center's Office of Community Outreach and Engagement (COE) transitioned cancer education efforts to virtual webinars and social media. These multilingual and multicultural efforts were targeted toward residents of Arizona, as well as a broader network of participants. Objective: To develop accessible, virtual programming to engage communities across Arizona during the COVID-19 pandemic to continue cancer education and health promotion efforts in bilingual (English and Spanish) webinars where possible. Methods: Utilizing a vibrant social media presence, the COE team developed a weekly webinar series, entitled Let's Taco 'Bout Cancer!, a monthly Morning Cat Chat webinar, and an annual Col-Chella festival that focuses on cancer education. These series are based on informal interviews and conversations with cancer researchers, community health partners, cancer survivors/caretakers, and community advisory board members. All presentations were streamed via Zoom, social media accounts, and YouTube to be accessible for later use. Lastly, demonstration webinars (e.g. food preparation) for healthy behaviors were also implemented. Results: Since March 2020, more than 22,000 viewers have been recorded over 122 virtual cancer-related presentations that were given. Sixty-one percent of the presentations were in English and 39% were in Spanish. Collected surveys indicate the median age of the audience is 55 years old, 77% females, and 43% community members. Twenty-nine (29) percent identify as Hispanic, 48% as non-Hispanic white, and 17% as American Indian/Alaska Native. Evaluations reported that 86% of the audience were engaged, 94% that their knowledge was increased, and 69% indicated that their knowledge is applicable. Eighty-seven (87) percent thought the research topics discussed benefits their community and 83% preferred to receive cancer education materials via email. The collected evaluations indicate the audience's top three priorities from the cancer center include: cancer prevention, education, and patient care. Discussion: Based on collected data, offering multicultural and multilingual outreach efforts virtually has allowed the COE team to continuously operate as an educational resource serving our diverse communities. Interacting and inviting members from Arizona's Hispanic and American Indian communities, along with health professionals, has made the Cancer Center more relative to the population it serves as well as allowing Arizona residents to hear from their own community. Overtime, in-person efforts will resume with the inclusion of virtual engagement to have a well-rounded approach.